Targeting the lysosome in cancer
Identifieur interne : 000D87 ( Main/Exploration ); précédent : 000D86; suivant : 000D88Targeting the lysosome in cancer
Auteurs : Shengfu Piao [États-Unis] ; Ravi K. Amaravadi [États-Unis]Source :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2016-05.
Abstract
Lysosomes are membrane‐bound intracellular organelles that receive macromolecules delivered by endocytosis, phagocytosis, and autophagy for degradation and recycling. Over the last decade, advances in lysosome research have established a broad role for the lysosome in the pathophysiology of disease. In this review, we highlight the recent discoveries in lysosome biology, with an emphasis on their implications for cancer therapy. We focus on targeting the lysosome in cancer by exploring lysosomal biogenesis and its role in the crosstalk between apoptosis and autophagy. We also discuss how lysosomal inhibition could emerge as a new therapeutic strategy to overcome drug resistance in cancer.
Url:
DOI: 10.1111/nyas.12953
Affiliations:
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